Wednesday, July 10, 2013

College Basketball: There's always next year

View PostRamsay Blow, on 08 April 2013 - 05:36 PM, said:

Damn Kentucky fans. They're everywhere. I remember going to MSG in December 2009 when Uconn played Kentucky, John Wall vs Kemba, there was like 80% Kentucky fans and Uconn is like a 2 hours drive from MSG(Kentucky won) I was amazed and disgusted.??Until the next year when Kemba went loco. But then I went to my only final 4 in New Orleans where Kentucky won.??I hate Kentucky and Calipari but I'm kind of like a good luck charm to you guys, unfortunately.??
Anyways, Uconn got that transfer Purvis from NC State so hopefully that's a step in the right direction so they can become a force again. March Madness was kinda empty for Uconn fans and Kentucky fans alike this year.


We are legion!

They don't call us the Blue Mist for nothing! And if you are that lucky, I will see about getting you 40 tickets for next year!??:lol:

Source: http://asoiaf.westeros.org/index.php/topic/84445-college-basketball-theres-always-next-year/

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Tuesday, July 9, 2013

National Air College, Inc., San Diego, CA

07/03/2013
National Air College, Inc., San Diego, CA
A Notice of Violation is issued, pursuant to Section 1.89 of the Commission's rules, to National Air College, Inc., operator of aircraft bearing FAA tail number N2171D in San Diego, CA.
Documents:
Word : DOC-322029A1.doc&nbsp
Acrobat : DOC-322029A1.pdf&nbsp
Text : DOC-322029A1.txt&nbsp

Source: http://hraunfoss.fcc.gov:80/edocs_public/index.do?document=322029

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Sunday, July 7, 2013

Has this slick concept made Apple's new Mac Pro 2013 even better? http://wp.me/p...

Sorry, Readability was unable to parse this page for content.

Source: http://www.facebook.com/SlashGear/posts/560873267285245

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Kris Jenner Pushing for North West Photo Deal, Banning Kim Kardashian from Leaving Home?

Source: http://www.thehollywoodgossip.com/2013/07/kris-jenner-pushing-for-north-west-photo-deal-banning-kim-kardas/

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Key events in Egypt's uprising and unrest

CAIRO (AP) ? Egypt's military-backed interim president dissolved the Islamist-dominated upper house of parliament on Friday as soldiers opened fire on mostly Islamist protesters in Cairo, killing at least one person.

The unrest comes after the military ousted President Mohammed Morsi, an Islamist, from power after several days of mass demonstrations against him.

Here are some key events from more than two years of turmoil and transition in Egypt:

Jan. 25-Feb. 11, 2011 ? Egyptians stage nationwide demonstrations against the rule of President Hosni Mubarak. Hundreds of protesters are killed as Mubarak and his allies try to crush the uprising.

Feb. 11 ? Mubarak steps down and turns power over to the military. The military dissolves parliament and suspends the constitution, meeting two key demands of protesters.

March 19 ? In the first post-Mubarak vote, Egyptians cast ballots on constitutional amendments sponsored by the military. The measures are overwhelmingly approved.

Oct. 9 ? Troops crush a protest by Christians in Cairo over a church attack, killing more than 25 protesters.

Nov. 28, 2011-Feb 15, 2012 ? Egypt holds multistage, weekslong parliamentary elections. In the lawmaking lower house, the Muslim Brotherhood wins nearly half the seats, and ultraconservative Salafis take another quarter. The remainder goes to liberal, independent and secular politicians. In the largely powerless upper house, Islamists take nearly 90 percent of the seats.

May 23-24, 2012 ? The first round of voting in presidential elections has a field of 13 candidates. Morsi and Ahmed Shafiq, the last prime minister under Mubarak, emerge as the top two finishers, to face each other in a runoff.

June 14 ? The Supreme Constitutional Court orders the dissolving of the lower house of parliament.

June 16-17 ? Egyptians vote in the presidential runoff between Morsi and Shafiq. Morsi wins with 51.7 percent of the vote.

June 30 ? Morsi takes his oath of office.

Aug. 12 ? Morsi orders the retirement of the top Mubarak-era leadership of the military.

Nov. 19 ? Members of liberal parties and representatives of Egypt's churches withdraw from the 100-member assembly writing the constitution, protesting attempts by Islamists to impose their will.

Nov. 22 ? Morsi unilaterally decrees greater powers for himself, giving his decisions immunity from judicial review and barring the courts from dissolving the constituent assembly and the upper house of parliament. The move sparks days of protests.

Nov. 30 ?Islamists in the constituent assembly rush to complete the draft of the constitution. Morsi sets a Dec. 15 date for a referendum.

Dec. 4 ? More than 100,000 protesters march on the presidential palace, demanding the cancellation of the referendum and the writing of a new constitution. The next day, Islamists attack an anti-Morsi sit-in, sparking street battles that leave at least 10 dead.

Dec. 15, Dec. 22 ? In the two-round referendum, Egyptians approve the constitution, with 63.8 percent voting in favor. Turnout is low.

Dec. 29 ? The Egyptian Central Bank announces that foreign reserves ? drained to $15 billion from $36 billion in 2010 ? have fallen to a "critical minimum" and tries to stop a sharp slide in the value of the Egyptian pound. It now stands at just more than 7 to the dollar, compared to 5.5 to the dollar in 2010.

Jan. 25, 2013 ? Hundreds of thousands hold protests against Morsi on the 2-year anniversary of the start of the revolt against Mubarak, and clashes erupt in many places.

Feb.-March 2013 ? Protests rage in Port Said and other cities for weeks, with dozens more dying in clashes.

April 7 ? A Muslim mob attacks the main cathedral of the Coptic Orthodox Church as Christians hold a funeral and protest there over four Christians killed in sectarian violence the day before. Pope Tawadros II publicly blames Morsi for failing to protect the building.

May 7 ? Morsi reshuffles his Cabinet. Officials say the changes aim to finalize long-stalled negotiations with the International Monetary Fund for a crucial $4.8 billion loan, which requires reductions to fuel and food subsidies. A deal on the loan has still not been reached.

June 23 ? A mob beats to death four Egyptian Shiites in a village on the outskirts of Cairo.

June 30 ? Millions of Egyptians demonstrate, calling for Morsi to step down. Eight people are killed in clashes outside the Muslim Brotherhood's Cairo headquarters.

July 1 ? Large-scale demonstrations continue, and Egypt's powerful military gives the president and the opposition 48 hours to resolve their disputes, or it will impose its own solution.

July 2 ? Military officials disclose main details of the army's plan if no agreement is reached: replacing Morsi with an interim administration, canceling the Islamist-based constitution and calling elections in a year. Morsi delivers a late-night speech in which he pledges to defend his legitimacy and vows not to step down.

July 3 ? Egypt's military chief announces that Morsi has been deposed, to be replaced by the Chief Justice of the Supreme Constitutional Court until new presidential elections. No time frame is given. Muslim Brotherhood leaders are arrested.

July 4 ? Supreme Constitutional Court Chief Justice Mansour Adly is sworn in as Egypt's interim president.

July 5 ? Adly dissolves the Islamist-dominated upper house of parliament as soldiers open fire on mostly Islamist protesters in Cairo demanding restoration of Morsi, killing at least one person.

Source: http://news.yahoo.com/key-events-egypts-uprising-unrest-122654089.html

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Thursday, July 4, 2013

YouTube Confirms Renewed VEVO Deal, Takes Stake In Company

Image (1) vevo-logo.png for post 111605YouTube confirmed that it has renewed its deal with music video distributor VEVO. Not only does the deal allow YouTube to keep VEVO's video on its site, but it also requires Google to invest in VEVO. Though terms of the deal have not been disclosed, Billboard estimated in February that it is worth between $40 million to $50 million and would give Google a 7 percent stake in VEVO.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/f0S9XYY9zYE/

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Batman In 'Justice League': With Christian Bale Out, Who's In?

With an 'Avengers'-style team-up a major possibility, the Dark Knight could look very different the next time we see him.
By Kevin P. Sullivan


Christian Bale As Batman
Photo: Warner Bros.

Source: http://www.mtv.com/news/articles/1709911/new-justice-league-batman.jhtml

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Tuesday, July 2, 2013

Death Valley temps at least tie record

LAS VEGAS (AP) ? Temperatures in Death Valley ? the legendary hottest place on Earth ? at least tied a record Sunday as a heat wave brought triple-digit highs across the West.

The National Weather Service's thermometer recorded a peak temperature of 128 degrees in Death Valley National Park, which ties the record for the hottest June day anywhere in the country.

However, the Los Angeles Times reports that the National Park Service thermometer ? 200 yards away ? recorded a temperature of 129.9, which shatters the record for June.

In Las Vegas, the mercury shot up to 117 degrees on Sunday to tie the city's record high and to cause more discomfort for residents and tourists in the sprawling desert city.

Since record-keeping began in Las Vegas in 1937, the only other times the temperature reached 117 degrees were on July 19, 2005, and July 24, 1942, according to the National Weather Service.

Death Valley's the record high of 134 degrees set nearly a century ago on July 10, 1913, stands as the planet's highest recorded temperature.

Triple-digit heat struck again elsewhere in Southern California, while metropolitan Phoenix saw just a slight drop in temperatures after experiencing record-breaking heat Saturday.

Six half-marathon runners in Southern California were hospitalized Sunday for heat-related illnesses. A day earlier, paramedics responding to a Nevada home without air conditioning found an elderly man dead.

Runners in the Southern California race who required medical attention were extremely dehydrated, and some experienced cramps, Pasadena Fire Department spokeswoman Lisa Derderian said. Several other runners were evaluated along the route but weren't taken to the hospital, she said.

Paramedics were deployed along the 13.1-mile race, and buses with air conditioning were provided for runners to cool off. The event was supposed to be a marathon, but it was downgraded due to low turnout last year.

Hikers, bikers and dog walkers were scarce on typically busy trails in the Santa Monica Mountains above Los Angeles. At midday, two women and a panting German shepherd huddled in a rare sliver of shade along a fire road before striking out in the hot sun.

Atop San Vicente Peak, cyclist Jeff Disbrow, 49, of Santa Monica was clad in black and lathered in sweat as he took a break and refilled his water bottle.

"It's not the best day to be out here ? unless you want to suffer," he said. "It's like Arizona."

In Utah, a record 105-degree heat caused an interstate on-ramp to buckle in Salt Lake City, and hampered firefighters in their battle against three wildfires. The Interstate 215 on-ramp had to be closed for four hours Saturday night after a short section of it expanded, Utah Department of Transportation spokesman John Gleason said.

The section looked like a pothole before it was repaved, he said. No problems were reported, and traffic was rerouted around the closed lane.

Phoenix Fire Department spokesman Larry Nunez said the city hasn't seen any deaths that were classified as heat-related, but emergency workers have gotten 98 heat-related calls within the metro area since Friday morning.

The 119-degree high in Phoenix on Saturday marked the fourth-hottest day in metro Phoenix since authorities started keeping temperature records more than 110 years ago. The high temperature for the metro area hit 115 on Sunday.

Temperatures could drop slightly in Phoenix within the coming days as monsoon storms are expected to make their way through the state. Such storms could bring cloud cover but could produce more humidity and possibly contribute to dust storms.

Several Southern California communities set same-day record highs Saturday including Palm Springs, where the mercury peaked at 122 degrees. In Northern California, Redding reported a high of 110, Sacramento had 107 while Fresno saw 109.

Source: http://news.yahoo.com/death-valley-temps-least-tie-record-034246832.html

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Sunday, June 30, 2013

'The Heat': The Reviews Are In!

MTV News rounds up what critics are saying about the action-comedy starring Sandra Bullock and Melissa McCarthy.
By Todd Gilchrist

Source: http://www.mtv.com/news/articles/1709745/the-heat-movie-reviews.jhtml

Prism

Wednesday, June 26, 2013

Australia-Japan whaling case begins

Public hearings are under way in The Hague as Australia and Japan take their fight over whaling to the International Court of Justice (ICJ).

Australia will argue that Tokyo's scientific research programme - under which it kills whales - is commercial whaling in disguise.

Japan - which aims to catch up to 1,000 whales each year - says it is ready to defend its right to conduct research.

There has been a ban on commercial whaling since 1986.

Australia initiated the legal action at the top UN court in 2010.

'Halted'

The first round of oral arguments began on Wednesday, with Australia taking the floor for three days to set out its case that Japan's position that its whaling activities are for scientific purposes "is not only untenable, it is dangerous" for whale populations.

Japan will make its counter arguments over three days from next Tuesday. A further round of arguments, including an intervention from New Zealand, will then take place with the case wrapping up on 16 July - though a ruling is then not expected for several months.

Continue reading the main story

The Legalities of Whaling

  • Objection - A country formally objects to the International Whaling Commission (IWC) moratorium, declaring itself exempt. Example: Norway
  • Scientific - A nation issues unilateral "scientific permits"; any IWC member can do this. Example: Japan
  • Indigenous (aka Aboriginal subsistence) - IWC grants permits to indigenous groups for subsistence food. Example: Alaskan Inupiat

Japan's whaling fleet leaves for the Southern Ocean in November or December each year, with a quota of of minke whales and fin whales whales to catch for what it says are scientific research purposes. Meat from the whales is sold commercially.

In recent years, catches have fallen substantially, mainly because of disruption techniques employed by anti-whaling activists.

Canberra alleges that the research programme breaches international laws and has no relevance to marine conservation. It says more than 10,000 whales have been killed under the programme.

"Australia's views on whaling are well established. We strongly oppose all commercial whaling, including so-called 'scientific' whale hunting by Japan," said Attorney-General Mark Dreyfus, who is representing Australia in court.

"We want to see the practice halted once and for all."

Tokyo says there are cultural reasons behind the annual hunt and that its whaling is sustainable. It also argues that its research provides information on whale stocks with a view to re-examining the ban on commercial whaling in the future.

"We have a scientific research programme in accordance with the convention on whaling and we are strictly abiding by the treaty obligations," government spokesman Noriyuki Shikata told the BBC.

New Zealand is supporting Australia at the ICJ and the court's decision is considered legally binding.

Source: http://www.bbc.co.uk/news/world-asia-23045457#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Tuesday, June 25, 2013

2013 Weekly Real Estate Market Report ? Week of: June 3rd to June ...

Coldwell Banker
2013 Weekly Real Estate Market Report
North Lake Tahoe-Truckee Region

Residential Properties ? Single Family Homes and Condominiums

Week of:? June 3rd to June 9th

Active Inventory Summary:

Active Listings: The current inventory of residential properties went up 2% from the previous week to 784 residential properties for sale; 589 single family homes and 195 condominiums for sale.? Coldwell Banker has over 15% of the active listings in the market and continues to be the market leader for listings.

REO-Short Sale Active Listings: Of the active listings, there are only 4 properties listed as short sales, (0.5%) and 7 properties listed as REO sales, (1%).

Months of Inventory: Based on the current active inventory and sales for the previous 30-day period, the market has just over 7-months of inventory available.

Sales Summary: Year-To-Date

Total Sales 2013 Vs. 2012:

Total Sales: For 2013, there have been 539 residential properties sold in the market which slightly higher than the 506 properties sold in 2012 for the same period.? Of the total sales in the market this year, 422 have been single family homes, while 117 or 22% of the sales are condominiums.? In 2012 for the same period, condominiums represented almost 25% of the sales.

REO & Short Sales: Distressed property sales are down significantly for the year with 35 REO sales, (6%), and 69 Short Sales, (13%) which results in 19% of the properties sold being distressed properties.? In 2012 for the same period, there were 97 REO sales and 95 short sales or 38% of the total sales being distressed properties.

Sales by Price Range: In 2013, there have been 316 residential properties sold priced below $500,000, 142 properties sold between $500,000 and $1,000,000 and 66 properties sold over $1,000,000.

Median and Average Sales Prices: The median sales price for properties sold year to date is $437,000 while the average sales price is $664,116. For the same period in 2012, the median sales price was $380,000 and the average sales price was $534,681 which is an increase of 15% in median sales price and an increase of 24% in average sales price.

Last Week?s Sales: For the week of June 3rd a total of 16 properties sold which was down significantly from the prior week?s sales of 24 properties.? Of the properties sold last week only 1 property sold at a price above $1,000,000.

Pending Sales: Currently there are 243 pending residential sales in the market which is up 4% from the previous week?s pending sales.? Of the pending properties, 21% are distressed properties with 41 being short sales and 12 being REO?s.

Market Activity Summary:

Residential sales activity for 2013 has been very favorable as we continue to see the market outpace 2012 for residential sales.? Thus far, 539 residential properties have sold year to date which is up 5% from the 506 sales for the same period last year.? We are continuing to see significant buyer interest for the Tahoe-Truckee market with multiple offer situations occurring more frequently than what we experienced last year.? June has gotten off to a slower start this year as compared to last year with 17 sales month to date as compared to 24 a year ago.? However, we are still seeing solid activity by interested Buyers.

Coldwell Banker Residential Brokerage for 2013 is #1 in the entire market in terms of both unit sides sold, (253 sales) and sales volume sold, ($107 million).

The median sales price for residential properties reached 437,000 last week which is up 15% from the median sales price of $380,000 in 2012.? Similarly the average sales price has gone up a whopping 24% to $664,116 as compared to last year?s average sales price of $534,681 due in large part to the higher number of luxury sales in the market since the beginning of the new year.

The segment of the market with the highest level of activity continues to be homes priced under $500,000 as 58% of the sales or 316 properties have sold in this price range which is similar to 2012 where over 64% of sales or 327 properties sold in this price range.

Luxury home sales, homes priced above $1,000,000, have gone up 78% from 2012 with 66 luxury properties selling since the beginning of the year as compared to only 37 luxury properties sold for the same period in 2012.? Luxury properties sold represent over 12% of sales thus far this year.? The median sales price for luxury properties in 2013 is $1,745,000 as compared to a median price of $1,300,000 in 2012 which is up 34%.? The average sales price of luxury homes in 2013 is $2,262,831 as compared to $2,154,316 in 2012 which is a 5% increase.

The mid range market sales, $500,000 to $1,000,000 are trending up from last year with 157 properties sold in this segment or 29% of sales as compared to 142 properties sold or 28% of sale in this range in 2012.

Distressed properties, (REO?s and Short Sales), have really lagged 2012 thus far.? For 2013, short sale properties closed have gone down 27% with 69 closed short sales in 2013 as compared to 95 closed short sales in 2012.? Similarly, REO properties closed in 2013 have gone down (64%) with 35 properties closed in 2013 as compared to 97 properties closed in 2012.? Overall, distressed property sales, (REO and Short Sales) represent 19% of the sales in 2013 which is less than the 38% in 2012.

The active inventory on a year over year basis is down roughly 17% as we currently have 784 residential properties listed for sale as compared to 951 a year ago at this time.? However, this past week we had a 2% increase in inventory bringing our total to 784 residential properties on the market; 589 single family homes and 195 condominiums listed for sale.

SUMMER IS AROUND THE CORNERR?IT?S NOT TOO LATE!? While inventory levels are lower than normal, there are still many quality properties to choose from throughout the north Lake Tahoe and Truckee area.? When you compound the inventory available with homes still priced at 10-year lows and some of the lowest interest rates in history, savvy real estate investors are taking advantage of this market and acquiring homes in many of the Lake Tahoe and Truckee resort communities.

Contact Realty for Truckee-Tahoe Team Today to Find Out More about the Opportunities Available in the Tahoe-Truckee Market.

Note: Data on this page is based on information from the Tahoe Sierra Board of Realtors, MLS.? Due to MLS reporting methods and allowable reporting policy, this data is only informational and may not be completely accurate.? Therefore, Coldwell Banker Residential Brokerage does not guarantee the data?s accuracy.? Data maintained by the MLS may not reflect all real estate activity in the market.? DRE License # 1908304

Source: http://www.realtyfortruckee.com/blog/2013/06/2013-weekly-real-estate-market-report/

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Merkel launches campaign with populist but costly promises

By Erik Kirschbaum

BERLIN (Reuters) - German Chancellor Angela Merkel launched her re-election campaign on Monday with promises her coalition partners dismissed as unaffordable and even one party ally said would never see the light of day.

Merkel told leaders of her Christian Democrats (CDU) and their Christian Social Union (CSU) sister party that if she is re-elected she wants to raise child benefits, pensions for women with children and pensions for low-income workers.

At the same time as preaching austerity to other euro zone nations struggling under high debt, Merkel said she wanted to see Germany invest billions more in infrastructure projects on top of the other multi-billion euro promises.

The pledges were criticized by the opposition and German media as expensive voter giveaways. One newspaper, Bild, estimated the increase in child benefits and pensions would total 15 billion euros per year. Most proposals have little chance, Bild said.

Merkel and CSU chairman Horst Seehofer, the Bavarian state premier who is also up for re-election in September, said there would be no tax increases to pay for the promises. The German economy is in solid shape with low unemployment.

Party leaders believe tax revenues will rise to 700 billion euros in 2017 from 600 billion in 2012 so no tax increases are needed. The government expects to have a balanced budget in 2014 and could even post a surplus soon.

"That would be the wrong way to go," said Merkel, referring to tax increases. She learned her lesson after nearly squandering a sure win in 2005 by pledging to raise value added tax (VAT) to 18 percent from 16 percent before the vote.

The conservatives were at 42 percent in polls just before the 2005 election but fell to 35.2 percent, in part due to Merkel's tax increase pledge, and were forced into an unwanted grand coalition with the centre-left Social Democrats (SPD).

Merkel, who is well ahead of the SPD in opinion polls but may not have enough support to renew her centre-right coalition with the FDP after the September 22 election, has been pushing hard to appeal to voters on the conservative and liberal wings of her party.

On Friday, in a gesture bound to appeal to voters on the conservative side, she told Russian President Vladimir Putin on a trip to St Petersburg that Germany wanted art looted by Soviet armies after World War Two repatriated.

Merkel's pledge to raise pensions has a historic precedent. Another CDU leader, Konrad Adenauer, won West Germany's only absolute majority (50.2 percent) in the 1957 election after promising to link pension increases to wage increases.

But those promises carry no appeal for her coalition partners, the Free Democrats (FDP). FDP chairman Philipp Roesler warned the conservatives against being led astray by the "sweet poison of spending money" before the election.

Also opposed to the spending spree, which the CDU calls a "government program" rather than an election program, is Kurt Lauk, head of the CDU economic council. He said these were only campaign promises and should not be taken seriously.

"Campaign promises are the things that parties promise to get elected," he said. "It's never happened before that election promises were turned directly into government programs. And all the voters know that from past experience."

Merkel's challenger, Peer Steinbrueck of the SPD, called the CDU/CSU campaign program "pre-meditated fraud".

(Editing by Alison Williams)

Source: http://news.yahoo.com/merkel-launches-campaign-populist-costly-promises-145212868.html

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Mumford & Sons announce rescheduled tour dates

NEW YORK (AP) ? Mumford & Sons are heading back on tour.

The Grammy-winning band announced Monday that it has rescheduled dates in Dallas; Woodlands, Texas; and New Orleans. The upcoming shows will include bassist Ted Dwane, who received treatment for a blood clot on his brain two weeks ago. The band postponed shows as a result, including a headlining gig at the Bonnaroo Music & Arts Festival.

The foursome's "The Full English Tour" will begin Aug. 26 in Toronto. It wraps Sept. 20 in Bonner Springs, Kan. Other stops include Milwaukee, Atlanta and Simpsonville, S.C.

The folk-rock band's sophomore album, "Babel," won album of the year at this year's Grammy Awards.

____

Online:

http://www.mumfordandsons.com/

Source: http://news.yahoo.com/mumford-sons-announce-rescheduled-tour-dates-183503695.html

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Monday, June 24, 2013

Soldiers work to move stranded in India mountains

GOVINDGHAT, India (AP) ? Soldiers worked on rocky gorges and rugged riverbanks Saturday trying to evacuate tens of thousands of people still stranded by monsoon flooding and landslides that killed nearly 600 people in northern India's Himalayas.

With bad weather and heavy rainfall predicted over the next two days, there was an added urgency to reach the approximately 22,000 people still stranded in the flood-hit Uttarakhand state, federal Home Minister Sushilkumar Shinde said.

Since helicopters could rescue only small groups of people at a time, army troops Saturday opened up another road route to the Hindu temple town of Kedarnath, worst affected by the floods that hit the mountainous region nearly a week ago.

Soldiers created rudimentary bridges by stringing rope across rocky riverbanks and gouged earth, enabling safe passage for civilians in areas where bridges and roads were swept away by the floods or blocked by debris and boulders.

Shinde said air force helicopters were dropping food and drinking water to those stranded in inaccessible areas.

Uttarakhand state spokesman Amit Chandola said late Saturday that more than 80,000 people have been rescued from the worst-hit districts by air and road since the rescue operations began.

At least 7,000 people were air-lifted by air force and privately-owned helicopters and transported to Uttarakhand's capital, Dehradun, on Saturday, he said.

Food, water and medicines were being supplied to the numerous relief camps that had been set up for the people rescued from the mountains until arrangements were made for the tourists to return home. Officials were also drawing up lists of local residents whose homes have been flattened to arrange compensation.

Officials say the death toll was expected to rise as troops reach remote hillside villages where flash floods washed away homes and boulders hurtled down on the fleeing villagers.

Around 10,000 army and paramilitary troops, members of India's disaster management agency and volunteers were involved in the rescue and relief efforts, Shinde said.

Uttarakhand state Chief Minister Vijay Bahuguna said Friday that 556 bodies were buried deep in slush caused by the landslides. Another 40 were found floating in the Ganges River.

Thousands of homes have been washed away or damaged in the state.

People across India are collecting clothes, blankets and tarpaulins and contributing money to help those left homeless in Uttarakhand.

Army engineers were rebuilding bridges and clearing roads to enable thousands of people to leave the region.

Uttarakhand is a popular summer vacation destination for hundreds of thousands of tourists seeking to escape the torrid heat of the plains. It is also a religious pilgrimage site with four temple towns located in the Garhwal Himalayan range.

The tourists usually head down to the plains before the monsoon breaks in July. But this year, early rains caught hundreds of thousands of tourists, pilgrims and local residents unaware.

Meteorological officials said the rains in Uttarakhand were the heaviest in nearly 80 years.

Google has launched an application, Person Finder, to help trace missing people in Uttarakhand. The version is available in both Hindi and English languages, according to a Google India blog.

Meanwhile, opposition parties and angry relatives in Uttarakhand accused the government of not doing enough to rescue people stranded in the temple towns.

Mukhtar Abbas Naqvi of the main opposition Bharatiya Janata Party accused the government of callousness toward those affected by the flooding.

"It is very unfortunate that the government cannot coordinate the rescue efforts and provide timely help to the survivors of this calamity," Naqvi told repoters.

Earlier Saturday, Shinde admitted that there had been gaps in the government's rescue and relief efforts due to a lack of coordination between several disaster and welfare agencies in Uttarakhand.

Sri Devi, a tourist from neighboring Nepal, said she and her companions took shelter in a building in Govindghat, a small town on the road to the Sikh holy site of Hemkund, after their car was washed away. The 60-year-old woman was among a group of stranded tourists rescued from the town.

"It was raining boulders down the mountain and then a flood of water swept away everything. The road was washed away and we were stuck for four days without any food," Devi said.

Monsoon flooding is an annual occurrence in India, causing enormous loss of life and property, and hundreds of people were missing and feared washed away in this week's torrential monsoon downpours and flash floods in the tributaries of the Ganges River.

Source: http://news.yahoo.com/soldiers-move-stranded-india-mountains-141123173.html

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Monday, April 29, 2013

The IPKat: The rise of patent monetization entities Part Three ...

In Part Two of this series of Katposts, we looked at the diffusion of patent assertion entities in England and Wales, where data show that only 6% of patent cases involve a PAE (in the US, instead, PAEs filed 56% of patent lawsuits in 2012 - see Part One). In the absence of detailed data on the rise of patent assertion entities in other EU countries, this Kat decided to take an indirect approach to the issue, looking at similarities or differences in (1) the usage of patents and (2) the legal framework in the UK and the rest of the EU.

On the first aspect, the PatVal-EU study provides some useful evidence on 'unused blocking patents', a concept that refers to patents which are neither used internally by the right owner, nor licensed. Their most frequent use is strategic blocking, which aims to prevent competitors from using the patented innovations. It is therefore probable that PAEs may assert patents falling within this category. A look at the findings of the PatVal-EU study shows that, in respect to about 9000 patents with priority date in 1993-1997 (located in France, Germany, Italy, Netherlands, Spain and UK), the share of unused blocking patents is between 12,6 and 23% [these data, coupled with similar data on unused sleeping patents, brought concerns about low patent valorization in the EU: the Commission, here and here, suggested that the development of patent funds and pools may increase valorization, but noted that their activities could lead to anti-competitive and hold-up practices, unless they were committed to non exclusive licensing, based on reasonable remuneration - similar private-public funds are starting to appear in Korea (Intellectual Discovery Fund), France (Brevets) and Japan (Innovation Network Corp.), as reported by Reuters here]. The highest percentage of unused blocking patents is found in the UK, which suggests that the number of PAE cases in the UK and in other EU countries should be comparable, unless the former has a peculiar legal framework which discourages PAEs from filing lawsuits at the PHC.

This finding is corroborated by a research conducted by S. Fusco, who found that the number of known PAE cases in Italy and Germany is particularly low. According to her paper, in the period 2000-2012, only five lawsuits involved a patent assertion entity in Italy (out of about 1,000 patent cases); in Germany, again, Fusco was only able to gather evidence of five PAE cases (out of about 8,000 patent cases) in the same span of time (although these data were collected through indirect evidence). A study that examined the activity of patent assertion entities in the German patent market also confirmed these data: T. Fischer and J. Henkel found that PAEs are not particularly active in the market for technology, a conclusion which falls in line with the UK data (particularly, with the low activity in patent filing and litigation). The researchers were able to identify only 107 patent transfers to known PAEs in Germany, while similar entities acquired 458 patents in the US [the data, however, also suggest that the entities operating in the EU differ from those active in the US and vice versa: of all the PAEs listed in the study, only Intergraph and Rambus had engaged in patent transfers in both markets]. Although there may not be an exact correspondence between patent transfers and litigation, this study certainly suggests that PAEs' activity in Germany remains low, as highlighted in Fusco's work.

Since (1) patent usage (and market) looks uniform, attention should be devoted to (2) the differences in the legal framework of patent litigation around Europe. If one or more of the elements that are commonly regarded as safeguards against the spread of PAE litigation cannot be found in one or more of the EU member states, it could mean that the reassuring data on PAE cases in England and Wales cannot be extended to other countries. Before digging deeper, however, it may be useful to list these 'safeguards'. According to several studies (for example, here and here), these elements comprise:
(a) strict rules on the patentability of software and business method;
(b) fragmented enforceability, which increases the costs and complexity of litigation (and the likelihood of inconsistent decisions);
(c) unavailability of contingency fees;
(d) low litigation costs and damage awards in comparison to the US [similarly, low damage awards appear to be a factor in limiting PAE litigation in India - thanks Rahul!];
(e) implementation of the 'loser pays' rule.
Although they may be interpreted in slightly different ways, these safeguards appear to be present all over the EU. However, the major threat comes from the fragmented enforceability, which brings with it the risk of conflicting decisions. This certainly increases the litigation's complexity, but also allows a patent assertion entity to exploit the inconsistencies to identify the most PAE-friendly courts (look here for a comparison between UK, Germany, France and Netherlands). A prime example of this risk may be found in the different attitude of the courts on the issuance of injunctions in PAE cases. Sir Robin Jacob, at the 2008 GRUR Meeting in Stuttgart, offered a humorous perspective on the issue, discussing the different approach of UK and German courts:
[I]t comes out of a little discussion I had with a prominent German lawyer. He said to me: "for us, there is no problem." "Why?" I said. "Because if a valid patent is infringed, there will be an injunction." "Suppose", I asked, "the patent was for a life saving drug and the patentee had not enough product to supply the market. Would a German court really stop the supply of an infringer?s product?" "Well", he said, conceding the point: "Maybe not. But it would have to be a very extreme case."
In Germany, an injunction is usually granted if there is a finding or likelihood of infringement, and its use as an incentive to force settlement is openly acknowledged. In the PAE case IPCom v HTC, a German judge held that:
The Chamber does assume in principle that the enforcement of a cease-and-desist claim can be disproportionate since rights arising from a patent are not granted without limits (Art. 14 (2) of the Basic Law, ? 242 of the German Civil Code). However, since the legislator does not make the cease-and-desist claim subject to any general prohibition on commensurability (not so: ? 140a (4), ? 140b (4), ? 140c (2), ? 140d (2) of the Patent Act) and the cease-and-desist claim secures the exclusivity right protected under constitutional law, the scope of the disproportionality defense remains restricted to atypical exceptional cases which could not be foreseen by the legislator. The fact that the patent licensing entity is attempting to enforce a cease-and-desist claim in order to urge infringing parties to pay for a license does not, in the view of the Chamber, constitute such an exception but rather is an inherent part of the patent system as part of the applicable legal and economic system, especially since a patent licensing entity will usually be urged to take such action with respect to existing license agreements.
The German approach seems at odds with the one taken by the PHC. Again, Sir Robin Jacob explained that judges in England and Wales are prepared to grant injunctions, but maintain a degree of discretion in relation to the relief, which they exercise taking into account the plaintiff's interest and previous conduct. He noted that UK courts reject absolutism and affirm the right to refuse an injunction when damages appear to be an adequate remedy. Reciting Seager v Copydex and Banks v EMI Songs, the former judge stated that 'where an inventor wanted to sell his idea for money, money is what he got'. A similar approach is adopted by courts in the Netherlands, which generally also exhibit a more sensitive attitude, than German courts, towards foreign judgments (head here and here for some food for thought on the topic). The practical consequence is that some companies are moving away from Germany, to relocate their headquarters in the Netherlands, citing legal concerns as the main reason for the relocation (Microsoft is probably the most prominent example - test your German here). The recent judgment of the CJEU in Case C?616/10, Solvay SA v Honeywell et al.?(IPKat comments here), stirred things up, as it recognized the possibility of granting pan-European injunctions, if there is 'a real connecting link between the subject-matter of the provisional measures sought and the territorial jurisdiction of the Member State of the court seised' (a paper just published offers a perspective on the case). The Court did not move away from its previous ruling in Case C-4/03, Gesellschaft f?r Antriebstechnik mbH & Co. v Lamellen und Kupplungsbau Beteiligungs, which taught that a national court may assess infringement (or non-infringement) beyond national boundaries, but cannot rule on the validity of the patent at issue, as the courts of the member state where the patent was registered have exclusive jurisdiction on questions of validity, pursuant to the mandatory rule of Article 22(4) of Regulation 44/2001 (Article 16(4) of the Brussels Convention). Instead, the judges recognized that a pan-European interim injunction is permitted, if it does not lead to a final decision on the patent's validity:
According to the referring court, the court before which the interim proceedings have been brought does not make a final decision on the validity of the patent invoked but makes an assessment as to how the court having jurisdiction under Article 22(4) of the regulation would rule in that regard, and will refuse to adopt the provisional measure sought if it considers that there is a reasonable, non-negligible possibility that the patent invoked would be declared invalid by the competent court. In those circumstances, it is apparent that there is no risk of conflicting decisions ..., since the provisional decision taken by the court before which the interim proceedings have been brought will not in any way prejudice the decision to be taken on the substance by the court having jurisdiction under Article 22(4) of Regulation No 44/2001.
Further, the Court ruled that Article 6(1) of Regulation 44/2001 may be applied in cases where two or more companies from different Member States, in proceedings pending before a court of one of those Member States, 'are each separately accused of committing an infringement of the same national part of a European patent which is in force in yet another Member State by virtue of their performance of reserved actions with regard to the same product'. In Actavis Group HF v Eli Lilly & Company, the High Court for England and Wales accepted to hear foreign patent claims (if no question of validity is involved), declining arguments pointing to the forum non conveniens (and the AdvoKat commented it here).

It is difficult to predict whether these recent development may fuel or hinder the rise of patent assertion entities in the EU. The prospect of obtaining a pan-European injunction could potentially help the spread of PAE cases, while pan-European infringement proceedings might reduce fragmentation, inconsistency and litigation costs. This Kat, however, does not think that these elements could cause a sudden surge in PAE litigation: on one side, the judges' attitude towards the issuance of injunctions in PAE cases has so far been cautious; on the other, fragmentation could be restored, and usually will, through an invalidity claim.

The same concerns expressed above accompanied the Unified Patent Court Agreement (UPC), which many studies depicted as a test for the EU patent litigation system's resistance to the diffusion of PAEs. In particular, commentators (European Scrutiny Committee report here) pointed to bifurcation, forum shopping (and pro-patentee attitude, determined by competition between local divisions - see a recap of issues here) and pan-European injunctions as the main issues that might transform the EU into a 'trolls' paradise'. Professor Harhoff?however stated that the UPC is designed with an emphasis on revocation, low costs and cautious use of injunctions, elements which should be adequate to counter 'trolling' activities. Certainly, that seems to be one of the aims of the UPC, as a recital states: '[w]ishing to improve the enforcement of patents and the defence against unfounded claims and patents which should be revoked and to enhance legal certainty by setting up a Unified Patent Court for litigation relating to the infringement and validity of patents'.

Of relevance to assess potential effects on PAE lawsuits are, inter alia, the following provisions:

* Article 19: the establishment of a training framework for the judges should ensure, or at least contribute to, the uniformity of judicial decisions among the different divisions (as expressly stated by the provision itself: 'Regular meetings shall be organised between all judges of the Court in order to discuss developments in patent law and to ensure the consistency of the Court's case law');
*?Article 33(1)(b): allowing the plaintiff to bring an action under Article 32(1)(a), (c), (f) and (g) against multiple defendants 'only where the defendants have a commercial relationship and where the action relates to the same alleged infringement' should prevent the EU from suffering from one of the issues that plagued US litigation before the America Invents Act, which introduced stricter joinder rules;
*?Article 33(3): bifurcation may be feared by many, but the real effects of the provision remain to be discovered, as two out of three options allow the case to proceed safely united. The risk, here, is that judges across the different divisions may adopt different practices with regard to bifurcation, effectively creating a pro-patentee enclave [shall we call it Eastern District for Europe, perhaps?];
*?Article 33(10): as evidenced by the study cited in Part One of this post, information asymmetry may play a key role in favouring PAE litigation [Merpel cannot make up her mind on whether the adoption of a fair play rule in patent litigation - or in any fields of litigation - would be beneficial or deadly];
*?Article 42: principles of proportionality and fairness, albeit theoretical premises which might be disregarded, certainly point the system in the right direction, as far as PAE (or any type of) litigation is concerned (e.g. they may influence the judges' decisions on bifurcation, when a patent assertion entity is concerned, concentrating litigation to avoid unfair use of the temporal discrepancy between the judgments of infringement and validity);
*?Article 62: discretionary grant of provisional injunctions challenges the courts with the task of defining clear and consistent standards, giving actual shape to the elements indicated in Article 62(2) (interests of the parties and potential harm from granting or refusal). Once again, as with bifurcation, uniformity appears to be the key to a PAE-proof system;
*?Article 63: similarly, allowing discretionary grant of permanent injunctions could lead courts to take a UK-inspired approach, limiting the award of permanent injunctions in PAE cases (again, uniformity is the issue here);
*?Article 69: the adoption of the 'loser pays' rule is likely to be a disincentive for exploratory lawsuits and is commonly thought to be a powerful antidote to PAE litigation.

On a train to Milan, the

Kat saw something familiar...

To this Kat, the risk that the UPC Agreement may provide fertile ground for PAE cases does not appear significantly higher than that embedded in the current situation. The system, however, seems characterized by a degree of fragmentation, and perhaps incoherency [as shown by readers' comments to a recent IPKat post], which makes it hard to foresee how judges are going to apply the provisions of the Agreement. Usually, trolling activity thrives in situations where complexity and confusion rule. Thus, the challenge that awaits judges, practitioners and scholars is to shed light on the obscure issues and to ensure that the divisions' decisions will be consistent and uniform [Merpel adds that a good starting point would be to address some of the Max Planck's criticisms, examined by the AmeriKat here].

The analysis conducted so far, in Parts Two and Three, showed that (1) England and Wales enjoy a relatively PAE-adverse environment, (2) PAE litigation in other EU member states is equally constricted, although there is some inconsistency with respect to the use of injunctions, (3) the trend towards pan-European litigation should not significantly alter the current situation, and (4) the UPC Agreement contains potentially dangerous provisions, whose effects can [should, says Merpel] be contrasted by an effort to achieve consistency and to establish clear and shared standards for issuing injunctive remedies and dealing with bifurcation.

There is still one issue which is worth mentioning, as it gives a preview of possible developments of PAE litigation in Europe. As highlighted at the beginning of Part Two, the expression 'patent assertion entity' commonly refers to a company who manages a portfolio of patents for the primary aim of assertion and litigation, without practising the invention. Recently, however, primary companies in the ICT sector started using PAEs (already existent or created ad hoc) to assert patents against each other, in an effort to gain a competitive advantage and to hold up competitors, relying on the ever growing phenomenon of patent thickets ('a dense web of overlapping intellectual property rights that a company must hack its way through in order to actually commercialize new technology' according to Shapiro, more here). In June 2012, for example, Google filed a complaint with the EU Commission, alleging that Microsoft and Nokia 'are colluding to raise the costs of mobile devices for consumers, creating patent trolls that sidestep promises both companies have made' (Guardian article here). The giant search-engine company demanded that the competitors be held accountable and invited the Commission to look into these practices. Further, intense litigation in the EU (and US) is currently surrounding standard essential patents and FRAND licensing (examples: Germany here and UK here).

It seems that, if the EU has been relatively immune from traditional patent trolling, a new wave of better looking, well dressed, yet secretly malicious PAEs is appearing on the horizon. A similar development would not only shake the safeguards that protected the EU from traditional PAE litigation, but would ultimately challenge the patent system itself, shifting the focus from protection of research and innovation, to strategic use of patents to alter competition on the merits. Thus closely observing and studying old and new PAEs, even if the phenomenon appears to be minor in the EU, might be a very wise thing to do.

Source: http://ipkitten.blogspot.com/2013/04/the-rise-of-patent-monetization_5980.html

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Tuesday, April 23, 2013

Dancer who lost foot in Boston bombing vows to take to the floor again

A week ago, Adrianne Haslet and her husband, Adam Davis, were watching the Boston Marathon from the sidelines. Then the bombs went off.

Davis, a U.S. airman, had just returned from Afghanistan.

"We sat up and I said, 'Wait, my foot hurts.' And then he held up my foot and we both just screamed bloody murder," she told ABC News today during a phone call from Boston Medical Center. "I didn't feel heat from it. I just felt air and then I fell to the ground."

The blast had torn off the dancer's left foot - a devastating loss for the ballroom dance instructor at Boston's Arthur Murray Studios. The bombings killed three people, including an 8-year-old boy, and injured at least 200 people.

Haslet, who appeared on the cover of the Boston Herald this morning, said she had not lost her spirit.

"I absolutely want to dance again," she said.

Dr. Linda Arslanian, a physical therapist at Boston's Brigham and Women's Hospital, said Haslett likely would dance again thanks to the advancement of prosthetic technology.

"If they were walking before they had their amputation, we can have them walk again," she said. "Much depends on the level of their amputation and all of it depends on what their goals and objectives are."

CLICK: Breakthroughs Will Benefit Boston Bombing Amputees

"If they want a vigorous life, we can give them a prosthesis that will allow huge amounts of versatility in their demands," Arslanian said. She did not treat Haslet.

Last year, ABC News interviewed Aimee Mullins, a model and athlete, who'd been born without shin bones and had to have legs amputated at the knee when she was a year old. With the aid of prosthetic legs, she became the first amputee to compete on an NCAA track team and competed in the 1996 Paralympics in Atlanta.

Haslet today said she was determined, like the rest of the city, to get back on her feet again.

"I just want people to know that you can come out of a situation that might seem like the end of the world and come out stronger," she said.

Also Read

Source: http://news.yahoo.com/blogs/abc-blogs/dancer-lost-foot-boston-marathon-bombing-vows-floor-021109058--abc-news-topstories.html

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Antibody transforms stem cells directly into brain cells

Apr. 22, 2013 ? In a serendipitous discovery, scientists at The Scripps Research Institute (TSRI) have found a way to turn bone marrow stem cells directly into brain cells.

Current techniques for turning patients' marrow cells into cells of some other desired type are relatively cumbersome, risky and effectively confined to the lab dish. The new finding points to the possibility of simpler and safer techniques. Cell therapies derived from patients' own cells are widely expected to be useful in treating spinal cord injuries, strokes and other conditions throughout the body, with little or no risk of immune rejection.

"These results highlight the potential of antibodies as versatile manipulators of cellular functions," said Richard A. Lerner, the Lita Annenberg Hazen Professor of Immunochemistry and institute professor in the Department of Cell and Molecular Biology at TSRI, and principal investigator for the new study. "This is a far cry from the way antibodies used to be thought of -- as molecules that were selected simply for binding and not function."

The researchers discovered the method, reported in the online Early Edition of the Proceedings of the National Academy of Sciences the week of April 22, 2013, while looking for lab-grown antibodies that can activate a growth-stimulating receptor on marrow cells. One antibody turned out to activate the receptor in a way that induces marrow stem cells -- which normally develop into white blood cells -- to become neural progenitor cells, a type of almost-mature brain cell.

Nature's Toolkit

Natural antibodies are large, Y-shaped proteins produced by immune cells. Collectively, they are diverse enough to recognize about 100 billion distinct shapes on viruses, bacteria and other targets. Since the 1980s, molecular biologists have known how to produce antibodies in cell cultures in the laboratory. That has allowed them to start using this vast, target-gripping toolkit to make scientific probes, as well as diagnostics and therapies for cancer, arthritis, transplant rejection, viral infections and other diseases.

In the late 1980s, Lerner and his TSRI colleagues helped invent the first techniques for generating large "libraries" of distinct antibodies and swiftly determining which of these could bind to a desired target. The anti-inflammatory antibody Humira?, now one of the world's top-selling drugs, was discovered with the benefit of this technology.

Last year, in a study spearheaded by TSRI Research Associate Hongkai Zhang, Lerner's laboratory devised a new antibody-discovery technique -- in which antibodies are produced in mammalian cells along with receptors or other target molecules of interest. The technique enables researchers to determine rapidly not just which antibodies in a library bind to a given receptor, for example, but also which ones activate the receptor and thereby alter cell function.

Lab Dish in a Cell

For the new study, Lerner laboratory Research Associate Jia Xie and colleagues modified the new technique so that antibody proteins produced in a given cell are physically anchored to the cell's outer membrane, near its target receptors. "Confining an antibody's activity to the cell in which it is produced effectively allows us to use larger antibody libraries and to screen these antibodies more quickly for a specific activity," said Xie. With the improved technique, scientists can sift through a library of tens of millions of antibodies in a few days.

In an early test, Xie used the new method to screen for antibodies that could activate the GCSF receptor, a growth-factor receptor found on bone marrow cells and other cell types. GCSF-mimicking drugs were among the first biotech bestsellers because of their ability to stimulate white blood cell growth -- which counteracts the marrow-suppressing side effect of cancer chemotherapy.

The team soon isolated one antibody type or "clone" that could activate the GCSF receptor and stimulate growth in test cells. The researchers then tested an unanchored, soluble version of this antibody on cultures of bone marrow stem cells from human volunteers. Whereas the GCSF protein, as expected, stimulated such stem cells to proliferate and start maturing towards adult white blood cells, the GCSF-mimicking antibody had a markedly different effect.

"The cells proliferated, but also started becoming long and thin and attaching to the bottom of the dish," remembered Xie.

To Lerner, the cells were reminiscent of neural progenitor cells -- which further tests for neural cell markers confirmed they were.

A New Direction

Changing cells of marrow lineage into cells of neural lineage -- a direct identity switch termed "transdifferentiation" -- just by activating a single receptor is a noteworthy achievement. Scientists do have methods for turning marrow stem cells into other adult cell types, but these methods typically require a radical and risky deprogramming of marrow cells to an embryonic-like stem-cell state, followed by a complex series of molecular nudges toward a given adult cell fate. Relatively few laboratories have reported direct transdifferentiation techniques.

"As far as I know, no one has ever achieved transdifferentiation by using a single protein -- a protein that potentially could be used as a therapeutic," said Lerner.

Current cell-therapy methods typically assume that a patient's cells will be harvested, then reprogrammed and multiplied in a lab dish before being re-introduced into the patient. In principle, according to Lerner, an antibody such as the one they have discovered could be injected directly into the bloodstream of a sick patient. From the bloodstream it would find its way to the marrow, and, for example, convert some marrow stem cells into neural progenitor cells. "Those neural progenitors would infiltrate the brain, find areas of damage and help repair them," he said.

While the researchers still aren't sure why the new antibody has such an odd effect on the GCSF receptor, they suspect it binds the receptor for longer than the natural GCSF protein can achieve, and this lengthier interaction alters the receptor's signaling pattern. Drug-development researchers are increasingly recognizing that subtle differences in the way a cell-surface receptor is bound and activated can result in very different biological effects. That adds complexity to their task, but in principle expands the scope of what they can achieve. "If you can use the same receptor in different ways, then the potential of the genome is bigger," said Lerner.

In addition to Lerner and Xie, contributors to the study, "Autocrine Signaling Based Selection of Combinatorial Antibodies That Transdifferentiate Human Stem Cells," were Hongkai Zhang of the Lerner Laboratory, and Kyungmoo Yea of The Scripps Korea Antibody Institute, Chuncheon-si, Korea.

Funding for the study was provided by The Scripps Korea Antibody Institute and Hongye Innovative Antibody Technologies (HIAT).

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/4sCqbLxIxUg/130422154756.htm

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Monday, April 22, 2013

FAA furloughs kick in, some flight delays appear

Commercial airline flights moved smoothly throughout most of the country on Sunday, the first day air traffic controllers were subject to furloughs resulting from government spending cuts, though some delays appeared in the late evening in and around New York. And even though the nightmarish flight delays and cancellations that the airline industry predicted would result from the furloughs did not materialize yet, the real test will come Monday, when traffic ramps up.

Information from the FAA and others showed that flying Sunday was largely uneventful, with most flights on time. There were delays in parts of Florida, but those were caused by thunderstorms.

Mark Duell at the flight tracking website FlightAware said that John F. Kennedy and LaGuardia airports in New York indicated delays due to lower staffing starting late Sunday evening. JFK averaged 70-minute delays for inbound flights, but no detectable departure delays. LaGuardia averaged 74-minute delays for inbound flights, and departure delays of 37 minutes.

The FAA website said that flights from Philadelphia and Orlando, Fla., into John F. Kennedy, LaGuardia and Westchester County airports were delayed due to staffing issues.

The trade group Airlines for America, which represents the airlines and had predicted a big traffic snarl, said Sunday evening that it was "not seeing a significant impact at this point." A spokeswoman said the group would continue to monitor the situation, and urged flyers to stay in contact with their airlines.

Delays were also affecting travelers in Los Angeles. The FAA said late Sunday night that staffing cuts were causing delays averaging more than three hours for flights arriving at Los Angeles International Airport. The agency did not say how many flights were affected.

Airport spokesman Marshall Lowe said about 70 flights had delays of about an hour or more Sunday, but he could not say what role the staffing cuts played in the delays.

The FAA said that "relatively good weather" and light traffic, which is typical of Sundays, helped keep delays in check. The agency said it would be working with airlines "to minimize the delay impacts of lower staffing" as the busy summer travel season approaches.

Government budget cuts that kicked in last month are forcing the FAA and other agencies to cut their spending. FAA officials have said they have no choice but to furlough all 47,000 agency employees, including nearly 15,000 controllers. Each employee will lose one day of work every other week. The FAA has said that planes will have to take off and land less frequently, so as not to overload the remaining controllers on duty.

Friday, airline trade groups and the country's biggest pilots union sued the FAA to try to stop the furloughs. They predicted that the furloughs would delay or cancel flights for as many as one out of every three airline passengers across the country. Airlines have also directed their customers to tell the FAA to find other ways to cut costs.

Source: http://news.yahoo.com/faa-furloughs-kick-flight-delays-appear-000550777--finance.html

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Big scramble seen in open Senate seat in Georgia (The Arizona Republic)

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Sunday, April 21, 2013

Boston's Ortiz set to return from 8-month layoff

BOSTON (AP) ? David Ortiz is set to make his return for the Boston Red Sox following an eight-month layoff.

Ortiz was in the batting order to hit cleanup and be the designated hitter in Saturday's game against the Kansas City Royals.

The 37-year-old was activated from the disabled list Friday. Ortiz injured his right Achilles tendon running the bases on July 17 and appeared just once in Boston's final 72 games, going 2 for 3 against the Royals on Aug. 24.

Ortiz was bothered by inflammation in both heels during spring training, and he went 4 for 18 (.222) with a home run during a six-game injury rehabilitation assignment with Triple-A Pawtucket from April 11-18.

Source: http://news.yahoo.com/bostons-ortiz-set-return-8-month-layoff-154246192--mlb.html

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Saturday, April 20, 2013

Penn receives prestigious national award for breakthrough in gene therapy

Penn receives prestigious national award for breakthrough in gene therapy [ Back to EurekAlert! ] Public release date: 19-Apr-2013
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Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Award recognizes improvements in human health and efforts to alleviate suffering from disease

PHILADELPHIA A gene therapy study focused on finding a cure for a rare congenital blinding disease has been recognized as one of the ten most outstanding clinical research projects of the year by the Clinical Research Forum (CRF). The study, led by Jean Bennett, MD, Phd, F.M. Kirby professor of Ophthalmology at the University of Pennsylvania School of Medicine, and carried out in collaboration with Penn Medicine's Albert M. Maguire, MD, and Katherine A. High, MD at The Children's Hospital of Philadelphia (CHOP), has been presented with the Distinguished Clinical Research Achievement Award, the second highest given in the CRF's Annual Top 10 Clinical Research Achievement Awards. CRF award winners are cited as the most compelling examples of scientific innovation that results from the nation's investment in clinical research that can benefit human health and welfare.

The results of the most recent phase of the study for Leber's Congenital Amaurosis (LCA) at CHOP have led to the first Phase 3 gene therapy study in the United States and the first Phase 3 gene therapy study in the world for a non-lethal disorder. The team of researchers hopes that the studies could lead to the first approved gene therapy product in the United States.

"The data from our study has already been used to develop additional clinical trials for other blinding diseases," said Bennett. "There are two things that I think are really going to be important from this work: one, that we'll move forward with this particular disease and get approval for the drug that we've been developing, and two, that this could ultimately lead to approved treatments for other currently untreatable conditions."

Published in 2012, the winning studies are the latest in a long tradition of notable health advances that have occurred through clinical research such as eliminating polio, reducing the mortality of AIDS, and improving cancer survival rates that were propelled by combined investment in basic science and clinical research.

"These patients, once rendered blind by LCA, have had their lives transformed and their vision restored by this team's efforts to further gene therapy research," said Joan O'Brien, MD, chair of the department of Ophthalmology at the Scheie Eye Institute at Penn Medicine. "The groundbreaking work sets the stage for the treatment of numerous other blinding conditions, but is also a shining example of what scientists with NIH resources can accomplish for the betterment of humanity."

###

The Clinical Research Forum is an organization comprised of the nation's most prestigious and acclaimed academic medical centers and healthcare systems whose goal is to sustain and expand a cadre of talented, well-trained clinical investigators at all stage of career development, and support nurturing environments and comprehensive research capabilities within academic institutions. Its mission is to provide leadership to the national clinical and translational research enterprise and promote understanding and support for clinical research and its impact on health.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.


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Penn receives prestigious national award for breakthrough in gene therapy [ Back to EurekAlert! ] Public release date: 19-Apr-2013
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Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Award recognizes improvements in human health and efforts to alleviate suffering from disease

PHILADELPHIA A gene therapy study focused on finding a cure for a rare congenital blinding disease has been recognized as one of the ten most outstanding clinical research projects of the year by the Clinical Research Forum (CRF). The study, led by Jean Bennett, MD, Phd, F.M. Kirby professor of Ophthalmology at the University of Pennsylvania School of Medicine, and carried out in collaboration with Penn Medicine's Albert M. Maguire, MD, and Katherine A. High, MD at The Children's Hospital of Philadelphia (CHOP), has been presented with the Distinguished Clinical Research Achievement Award, the second highest given in the CRF's Annual Top 10 Clinical Research Achievement Awards. CRF award winners are cited as the most compelling examples of scientific innovation that results from the nation's investment in clinical research that can benefit human health and welfare.

The results of the most recent phase of the study for Leber's Congenital Amaurosis (LCA) at CHOP have led to the first Phase 3 gene therapy study in the United States and the first Phase 3 gene therapy study in the world for a non-lethal disorder. The team of researchers hopes that the studies could lead to the first approved gene therapy product in the United States.

"The data from our study has already been used to develop additional clinical trials for other blinding diseases," said Bennett. "There are two things that I think are really going to be important from this work: one, that we'll move forward with this particular disease and get approval for the drug that we've been developing, and two, that this could ultimately lead to approved treatments for other currently untreatable conditions."

Published in 2012, the winning studies are the latest in a long tradition of notable health advances that have occurred through clinical research such as eliminating polio, reducing the mortality of AIDS, and improving cancer survival rates that were propelled by combined investment in basic science and clinical research.

"These patients, once rendered blind by LCA, have had their lives transformed and their vision restored by this team's efforts to further gene therapy research," said Joan O'Brien, MD, chair of the department of Ophthalmology at the Scheie Eye Institute at Penn Medicine. "The groundbreaking work sets the stage for the treatment of numerous other blinding conditions, but is also a shining example of what scientists with NIH resources can accomplish for the betterment of humanity."

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The Clinical Research Forum is an organization comprised of the nation's most prestigious and acclaimed academic medical centers and healthcare systems whose goal is to sustain and expand a cadre of talented, well-trained clinical investigators at all stage of career development, and support nurturing environments and comprehensive research capabilities within academic institutions. Its mission is to provide leadership to the national clinical and translational research enterprise and promote understanding and support for clinical research and its impact on health.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/uops-prp041913.php

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